Registered Nurses Salary in St. Louis, MO-IL: $83,180 Median Pay (May 2025 estimates)

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Median annual pay

$83,180 / year

14.7% below the national median

$42.46

Mean hourly wage

$88,310

Mean annual wage

35,200

Jobs in St. Louis

$39.99

Median hourly wage

Registered Nurses pay in St. Louis, MO-IL: the full picture

Registered Nurses in St. Louis, MO-IL earn a median of $83,180 per year ($39.99 per hour), based on May 2025 estimates (released April 2026) from the U.S. Bureau of Labor Statistics. The mean annual wage is $88,310, across an estimated 35,200 jobs. That puts St. Louis 14.7% below the national median of $97,550 for registered nurses.

Measure	Pay
Mean hourly wage	$42.46
Median annual wage	$83,180
Mean annual wage	$88,310
Median hourly wage	$39.99
Total employment	35,200

How St. Louis compares

Median annual pay for registered nurses across the areas we track. The national median is included for reference.

St. Louis

$83,180

San Jose

$216,740

San Francisco

$186,610

Sacramento

$171,460

California

$140,270

Frequently asked questions

How much does a RN make in St. Louis?

The median annual wage is $83,180 ($39.99/hour). The mean is $88,310 per year.

Is St. Louis a good place for registered nurses pay-wise?

St. Louis pays 14.7% below the national median ($97,550), with about 35,200 jobs in the area.

Where does this data come from?

All figures are May 2025 estimates (released April 2026) from the U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), retrieved 2026-10-09. They are survey estimates, not job offers.

Keep exploring

More Registered Nurses salary data and other nursing roles in St. Louis, MO-IL.

Sources & methodology. All figures on this page come from the U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates (released April 2026), retrieved 2026-10-09. "Median" is the 50th percentile — half of workers earn more, half earn less. "Mean" is the arithmetic average. Annual figures assume full-time, year-round work (2,080 hours). Employment estimates exclude the self-employed. Figures are rounded survey estimates, not job offers — actual pay varies by employer, shift, experience, and certifications.