Nurse Practitioners Salary in St. Louis, MO-IL: $131,580 Median Pay (May 2025 estimates)

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Median annual pay

$131,580 / year

0.5% below the national median

$65.17

Mean hourly wage

$135,550

Mean annual wage

3,430

Jobs in St. Louis

$63.26

Median hourly wage

Nurse Practitioners pay in St. Louis, MO-IL: the full picture

Nurse Practitioners in St. Louis, MO-IL earn a median of $131,580 per year ($63.26 per hour), based on May 2025 estimates (released April 2026) from the U.S. Bureau of Labor Statistics. The mean annual wage is $135,550, across an estimated 3,430 jobs. That puts St. Louis 0.5% below the national median of $132,300 for nurse practitioners.

Measure	Pay
Mean hourly wage	$65.17
Median annual wage	$131,580
Mean annual wage	$135,550
Median hourly wage	$63.26
Total employment	3,430

How St. Louis compares

Median annual pay for nurse practitioners across the areas we track. The national median is included for reference.

St. Louis

$131,580

San Jose

$231,560

San Francisco

$219,080

Sacramento

$172,010

California

$168,520

Frequently asked questions

How much does a NP make in St. Louis?

The median annual wage is $131,580 ($63.26/hour). The mean is $135,550 per year.

Is St. Louis a good place for nurse practitioners pay-wise?

St. Louis pays 0.5% below the national median ($132,300), with about 3,430 jobs in the area.

Where does this data come from?

All figures are May 2025 estimates (released April 2026) from the U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), retrieved 2026-10-09. They are survey estimates, not job offers.

Keep exploring

More Nurse Practitioners salary data and other nursing roles in St. Louis, MO-IL.

Sources & methodology. All figures on this page come from the U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics (OEWS), May 2025 estimates (released April 2026), retrieved 2026-10-09. "Median" is the 50th percentile — half of workers earn more, half earn less. "Mean" is the arithmetic average. Annual figures assume full-time, year-round work (2,080 hours). Employment estimates exclude the self-employed. Figures are rounded survey estimates, not job offers — actual pay varies by employer, shift, experience, and certifications.